Release of kallikrein from isolated rat kidney by a high potassium
نویسندگان
چکیده
منابع مشابه
Dexamethasone, aldosterone and kallikrein release by isolated rat kidney.
1. The effect of D-aldosterone and dexamethasone on kallikrein release was studied in the isolated rat kidney perfused with modified Krebs-Henseleit buffer. 2. Animals received D-aldosterone or dexamethasone (10 microgram/100 g body weight) daily for 3 days. Their isolated kidneys were then perfused with the same steroids at rates of 2.0-2.5 microgram/min for 30 min. 3. Dexamethasone increased ...
متن کاملRelease of activatable kallikrein by isolated rat kidneys.
Rat isolated kidneys were perfused for 60 minutes with a modified Krebs-Henseleit bicarbonate solution. Perfusate and urine samples showed kininogenase activity (active kallikrein) which could be enhanced by activation with trypsin (activatable kallikrein). Identification of the kininogenase activity generated by trypsin was made with rat renal kallikrein antiserum, aprotinin, lima bean trypsin...
متن کاملPotassium transport by the isolated perfused kidney.
Rat kidneys perfused outside of the body with an artificial medium are able to increase their fractional excretion of potassium in response to a rising concentration of potassium in the medium but never show net secretion of potassium. By contrast, isolated perfused kidneys from chronically potassium-loaded rats regularly secrete potassium in excess of the amount filtered. Ouabain completely bl...
متن کاملDirect action of rat urinary kallikrein on rat kidney to release renin.
To study the effect of kallikrein on renal renin release, we superfused rat renal cortical slices with 3.5 to 140 milliesterase units (mEU)/ml of purified rat urinary kallikrein. Kallikrein was a potent stimulus of renin release. Renin rose in a dose-dependent fashion from 70 mEU/ml to 140 mEU/ml. The response to 140 mEU/ml was greater than that seen with maximal doses of prostaglandin E2 (170 ...
متن کاملStimulation by octanoate of insulin release from isolated rat pancreas.
Using pieces of rat pancreas incubated bation medium to 3.0 mg./ml. without in Krebs-bicarbonate buffer containing addition of octanoate produced a slight0.6 mg. glucose/ml., it has been found ly smaller though significant (p < .05) that addition of 3.0 mM. octanoate to increase in insulin release (2.96 t 0.96 the incubation medium significantly (p &J./mg.) above control levels. In con< .OOl) i...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)41095-0